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KMID : 0617220030140010219
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Duksung Bulletin Phamaceutical Sciences
2003 Volume.14 No. 1 p.219 ~ p.229
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Hepatotoprotective Effects of Synthetic 3-Alkoxy-6-allylthiopyridazine Derivatives on Aflatoxin B_(1)-induced chronic or acute toxicity
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Abstract
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3-Alkoxy-6-allylthiopyridazine derivatives were synthesized and their hepatoprotective activities were studied by Aflatoxin B_(1) administration. Male Sprague-Dawley rat were pretreated with 3-alkoxy-6-allylthiopyridazine derivatives at the daily oral doses of 50mg/kg for 10 consecutive days, and during this period single dose (3.0mg/kg, i.p.) or three repeated doeses (1.0mg/kg, i.p.) of Aflatoxin B_(1) injected. In the experimental result, the ratio of the liver to body weights of rats in the AFB_(1)-treated and control group was no different. Pretreatment with the 3-alkoxy-6-allylthiopyridazine, K6, K8, K16, K17 and K18, inhibited the body weight reduction induced by AFB_(1) administration. The effect of five 3-Alkoxy-6-allylthiopyridazine derivatives completely decrease in AFB_(1)-induced elevation of ALT and AST activities, respectively.
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KEYWORD
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